Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

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Abstract Fungal infections caused by Candida spp.represent an emerging problem during treatment of immunocompromised patients and those hospitalized with serious principal diseases.The ever-growing number of fungal strains exhibiting drug turbo air m3f72-3-n resistance necessitates the development of novel antimicrobial therapies including those based on membrane-permeabilizing agents and nanomaterials as drug carriers.In this study, the fungicidal activities of LL-37 peptide, ceragenin CSA-13 and its magnetic derivatives (MNP@LL-37, MNP@CSA-13) against laboratory and clinical strains of C.

albicans, C.glabrata and C.tropicalis were evaluated.These experiments confirm the high anti-fungal activity of these well-characterized agents mediated by their interaction with the fungal membrane and demonstrate elevated activity following immobilization of LL-37 and CSA-13 on the surface of magnetic nanoparticles (MNPs).

Furthermore, MNP-based nanosystems are resistant to inhibitory factors present in body fluids and effectively inhibit the gel bottle cashmere formation of fungal biofilm.Simultaneously, synthesized nanostructures maintain immunomodulatory properties, described previously for free LL-37 peptide and CSA-13 substrate and they do not interfere with the proliferation and viability of osteoblasts, confirming their high biocompatibility.